Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs
نویسندگان
چکیده
منابع مشابه
Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.
BACKGROUND We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular events in patients with coronary artery disease. The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse. METHODS AND RESULTS Female apolipoprotein E-deficient mic...
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BACKGROUND Human herpesviruses have been implicated but not proven to be involved in the etiology of atherosclerosis. To determine whether there is a causal relationship, the effect of herpesvirus infection on the development of atherosclerosis was assessed in the apolipoprotein E-deficient (apoE-/-) mouse. METHODS AND RESULTS In the present study, 3- to 4-week-old apoE-/- mice were infected ...
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Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to cosmic radiation might pose a similar risk for astronauts has increased. To address this question, we examined the effect of 2 to 5 Gy iron ions ((56)Fe), a particularly damaging component of cosmic radiation, targeted to specific arterial ...
متن کاملMelanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E−/− Mice
OBJECTIVE The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 (ATP-binding cassette transporter subfamily A member 1) and ABCG1 (ATP-binding cassette transporter subfamily G member 1). In this study, we aime...
متن کاملPeroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.
RATIONALE Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress. OBJECTIVE Although Prdx2 has been proposed to retard atherosclerosis development, no direct evidence and mechanisms have been reported. METHODS AND RESULTS We show that Prdx2 is highly expressed in endothelial and immune c...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2018
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.036632